Stroke Treatment Technology

Unmet Clinical Need

Current Technology Stentriever vs Small Bore Aspiration First Pass Effect

CURRENTLY, 50% OF PATIENTS TREATED ACHIEVE LESS THAN OPTIMAL OUTCOMES

despite recent improvements in treatment technology^2,3

Time is Brain

TODAY’S TECHNOLOGY HAS LIMITATIONS

Physicians cannot access the blocked vessels with a device diameter suitable for complete clot removal.

Requires physicians to drag the clot which may cause fragmentation and lead to new vessel occlusions and ischemia.

Necessitates multiple passes (average 2; range 1-6), extending procedure time and increasing the potential for vessel trauma.

CURRENT TECHNOLOGY

TWO OPTIONS ON MARKET TODAY

Stentrievers

Small Bore Aspiration

Stentriever

Small Bore Aspiration

Requires passing a microwire and mirocatheter through the clot which may cause fragmentation

Requires dragging of the clot which may cause fragmentation

Metal scraping of the stentriever struts can cause pain or vessel wall damage

Low first pass complete revascularization (30%)⁴

Requires multiple attempts to extract clot^5-7

Increased need to bailout using alternative (24% & 33% of cases respectively)⁸

FIRST PASS EFFECT: ACHIEVING COMPLETE REPERFUSION ON THE FIRST PASS

Results in a 1.8x increase in a positive outcome after stroke¹⁰

Currently achieved in less than 30% of cases ¹⁰

The unmet clinical need remains for a simple, repeatable solution to completely reperfuse an occluded brain blood vessel in a single pass.

Our Solution

Proportions of Patients with Good Outcomes

References

(2) Nogueira et al. Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct. N. Engl. J. Med. 2016

(3) Albers etal.. Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging. N. Engl. J. Med. 2018

(4) Ducroux et al. First Pass Effect with Contact Aspiration and Stent Retrievers in the Aspiration versus Stent Retriever (ASTER) Trial. J. Neurointerventional Surg. 2020

(5) Tonetti et al. Successful Reperfusion, Rather than Number of Passes, Predicts Clinical Outcome after Mechanical Thrombectomy. J. NeuroInterventional Surg. 2020

(6) García-Tornel et al. When to Stop: Detrimental Effect of Device Passes in Acute Ischemic Stroke Secondary to Large Vessel Occlusion. Stroke 2019

(7) Duffy et al. Per-Pass Analysis of Thrombus Composition in Patients with Acute Ischemic Stroke Undergoing Mechanical Thrombectomy. Stroke 2019

(8) Lapergue et al. The ASTER Randomized Clinical Trial.. JAMA 2017

(9) Goyal et al. Endovascular Thrombectomy after Large-Vessel Ischaemic Stroke: A Meta-Analysis of Individual Patient Data from Five Randomised Trials. The Lancet 2016

(10) Zaidat et al. First Pass Effect - A New Measure for Stroke Thrombectomy Devices. Stroke 2018